罗替戈汀微球体外释放度的检查方法

分别采用摇床法和流通池法测定罗替戈汀微球的体外释放度,并通过与体内药动学曲线拟合进行选择.结果表明,摇床法和流通池法测定的体外释放度均与体内吸收具有明显相关性,相关系数r分别为0.9937和0.9978,且流通池法可检测到微球存在的较小突释.摇床法和流通池法均可用于罗替戈汀微球的体外释放度检查,流通池法作为一种新型溶出...     

1,3-双(1-苯基-1H-四唑-5-巯基)-乙酰苯腙钳形受体对卤素阴离子的识别机理

采用密度泛函B3LYP(Becke, three-parameter, Lee-Yang-Parr)和HF(Hatree-Fock)方法, 从理论上探讨了1,3-双(1-苯基-1H-四唑-5-巯基)-乙酰苯腙(DAPHZ)钳形受体对卤素阴离子的识别机理,结果发现DAPHZ受体以其钳形结构中的-N-H基团与卤素阴离子间形成双侧红移氢键进行识别. 经BSSE校正后DAPHZ•••F-, DAPHZ•••Cl-和DAPHZ•••Br-体系的分子识别相互作用能ΔECP分别为-327.5,-163.5和-148.3 kJmol-1, 说明钳形DAPHZ受体对F-具有最好的识别能力. 此外, 采用自然键轨道(NBO)计算, 相关H原子化学位移计算及分子中原子(AIM)等理论分析了识别体系中红移氢键的电子结构和性质, 结果表明APHZ受体对卤素阴离子的识别能力的相对顺序为DAPHZ•••F- >> DAPHZ•••Cl- ≈ DAPHZ•••Br-.     

Minimum total coloring of planar graph

Graph coloring is an important tool in the study of optimization, computer science, network design, e.g., file transferring in a computer network, pattern matching, computation of Hessians matrix and so on. In this paper, we consider one important coloring, vertex coloring of a total graph, which is familiar to us by the name of “total coloring”. Total coloring is a coloring of \(V\cup {E}\) such that no two adjacent or incident elements receive the same color. In other words, total chromatic number of \(G\) is the minimum number of disjoint vertex independent sets covering a total graph of \(G\) . Here, let \(G\) be a planar graph with \(\varDelta \ge 8\) . We proved that if for every vertex \(v\in V\) , there exists two integers \(i_{v},j_{v} \in \{3,4,5,6,7,8\}\) such that \(v\) is not incident with intersecting \(i_v\) -cycles and \(j_v\) -cycles, then the vertex chromatic number of total graph of \(G\) is \(\varDelta +1\) , i.e., the total chromatic number of \(G\) is \(\varDelta +1\) .     

目标规划中权系数的几何意义

本用平面仿射坐标的观点，解释了目标规划中权系数的几何意义，借助于坐标变换，可改进图解法的效果。     

A Convenient Synthesis of N-Methoxy-N-Methylamides from Carboxylic Acids

Carboxylic acids can be converted to their corresponding N-methoxy-N-methylamides in high yields using 2-chloro-1-methylpyridinium iodide as the coupling agent. The reaction proceeds without racemization when chiral carboxylic acids are used as the starting material.     

Three New Coumarins from Micromelum integerrimum

Micromelum integerrimum (Rutaceae) is a shrub growing in Yunnan Province. Leaves and barks of this plant have been used for the treatment of dysentery, and arthritis1. Previous researches revealed that this plant contained coumarins2-8. Micromelin, the main chemical constituent of this plant, showed significant inhibition against leukaemia P-388 cell line (T/C 149% at 10 mg/kg) but was inactive in lower doses, and also showed significant activity (T/C 228% at 1.25 mg/kg) against Lewis lung…     

基于属性测度的决策系统研究

在属性集和属性测度理论基础上系统地讨论了属性测度综合评价和决策系统.把综合决策系统分为三个子系统;第一个为单指标性能函数分析子系统,第二个为多指标综合性能函数分析子系统;第三个为识别分析子系统.并在属性测度决策系统的基础上,给出了一个应用实例.通过实例的分析,表明该系统是合理、实用和有效的.     

闭区间[0,1]上的分形插值函数的分数阶积分

介绍了分形插值函数和迭代函数系统以及v阶黎曼-刘准尔分数阶积分的概念及相关定理.利用这些概念及定理讨论了分形插值函数的分数阶积分在[0,1]上连续性及判定[0,1]上的分形插值函数的分数阶积分也是[0,1]上的分形插值函数,并给予了证明.